Endep: Drug Information

Other names: Tryptizol, Perphenazine, Amitone, Eliwel, Sarotena, Tadamit, Tryptomer, Kamitrin, Latilin

Drug Class: Tricyclic, Antidepressant

Uses of Endep:

Endep is a tricyclic antidepressant that is used to treat major depression, particularly associated with sleep disturbances. It is also used in the treatment of anxiety that is caused by depression. Imbalance of neurotransmitters in the brain can cause depression in some individuals. Endep helps cure this imbalance by blocking the neuronal reuptake of adrenaline and serotonin, thereby treating depression. This medicine is also known to have a sedative action and can cause drowsiness. Endogenous depression responds best to this type of medication.

How to take the medicine?

You must take the medicine as prescribed by your doctor who may gradually increase the dosage. You can take Endep with food before bedtime or late in the afternoon. This medicine is NOT recommended for children below the age of 12 years and caution is advised while administering it to the elderly.

Warning and Precautions:

Tell your doctor if you are allergic to any medicines or foods.

You must notify your doctor if you are pregnant or lactating before taking Endep.

If you have a medical history of hypersensitivity, bipolar depression, conduction abnormalities, cardiovascular disease, liver disease, psychosis, asthma, enlarged prostrate, thyroid disorder, epilepsy, kidney disease, brain tumor or are recovering from MI, you need to tell your doctor.

Endep should NOT be given to patients on mono amine oxidase inhibitors (MAOIs).

DO NOT take alcohol with Endep as it increases drowsiness.

Drug Interactions:

Endep should NOT be given with Barbiturates as it reduces the serum level. Tell your doctor if you are on narcoleptics as taking the medicine with inhibit metabolism. Antiparkinson agents and antipsychotic drugs need to be avoided with Endep. The medicine should not be taken with MAOIs as it may result in convulsions, marked hyperplexia or coma.

Side Effects:

Some of the most common side effects of Endep include tachycardia, confusion, dizziness, postural hypotension, cardiac arrhythmias, urinary retention, blurred vision, confusion, delirium, headache, sexual dysfunction, weight gain, tremors, constipation and weakness.